Advances in two-component signal transduction system VraSR of Staphylococcus

VernacularTitle:葡萄球菌万古霉素耐药相关双组分系统VraSR研究进展
Author: Hongling CHEN ¹ ; Yuanyuan MENG ; Youcong WU ; Li BAI ; Di QU
Author Information

1. 大理大学基础医学院病原生物学综合实验室 671000
Keywords: Two-component signal transduction system; VraSR; Staphylococcus
From:Chinese Journal of Microbiology and Immunology 2019;39(2):150-156
CountryChina
Language:Chinese
Abstract: Staphylococcus utilizes vancomycin-resistance associated sensor/regulator ( VraSR) , a two-component signal transduction system ( TCS) , to sense and respond to cell wall damage and to adapt to environmental changes through regulating transcriptions of downstream genes. It has been indicated that VraSR can regulate the transcription of a series of genes involved in the synthesis of peptidoglycan, drug re-sistance, and virulence in Staphylococcus aureus ( S. aureus) . A similar two-component system, VraSR, is also present in Staphylococcus epidermidis ( S. epidermidis ) , sharing a high homology with the VraSR of S. aureus. Little is known about the functions of VraSR in S. epidermidis and it is not yet clear what the simi-larities and differences in resistance and pathogenicity are. Based on the previous work of our group, a brief review on the regulation mechanism of staphylococcal VraSR was performed.