Progress in the mechanism of glycometabolism in memory CD8+ T cell formation
10.3760/cma.j.issn.0254-5101.2019.02.012
- VernacularTitle:糖代谢在记忆CD8+T细胞形成中的作用研究进展
- Author:
Jingjing YAN
1
;
Mingbin LIU
;
Jianqing XU
;
Xiaoyan ZHANG
Author Information
1. 复旦大学附属公共卫生临床中心
- Keywords:
Glycometabolism;
Glycolysis;
mTOR;
Memory T cell
- From:Chinese Journal of Microbiology and Immunology
2019;39(2):145-149
- CountryChina
- Language:Chinese
-
Abstract:
CD8+T cells are critical immune cells protecting the body against infection and cancer. Long-lived memory CD8+T cells formed in a prior infection can reproduce to mount a faster and stronger im-mune response at a second encounter with the cognate antigen. The activation, clonal expansion and re-sponse of T cells are energetically demanding processes tightly coupled in cellular metabolism. Meanwhile, changes in cellular metabolism could also affect the development of memory T cells following acute infection. In this review, we discussed the current understanding of the mechanism by which glycometabolic pathways manipulate the differentiation of memory CD8+T cells in order to provide reference for improving vaccine de-velopment and cancer treatment.
