Expression of vascular endothelial growth factor and its vital catalytic role in promotion of invasion and metastasis of hepatocellular carcinoma cells
10.3760/cma.j.issn.0254-5101.2019.01.012
- VernacularTitle:血管内皮生长因子表达及其对肝癌细胞侵袭转移的促进作用
- Author:
Jian WANG
1
;
Cundi LI
;
Weiya CAO
Author Information
1. 安徽理工大学医学院病原生物学教研室
- Keywords:
Vascular endothelial growth factor;
Hepatocellular carcinoma cell;
Angiogenesis;
In-vasion;
Metastasis;
Targeted therapy
- From:Chinese Journal of Microbiology and Immunology
2019;39(1):73-78
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor ( VEGF) is a mitogen that specifically acts on glyco-sylated cells of endothelial cells, enhances vascular permeability, induces angiogenesis, promotes the growth, invasion and metastasis of hepatocellular carcinoma cells. The prognosis of patients with high expres-sion of vascular endothelial growth factor is poor. Down-regulation of VEGF can significantly inhibit the ma-lignant proliferation of hepatocellular carcinoma ( HCC) and improve patients′ prognosis. This article sys-tematically reviewed the recent advances in VEGF expression and its role in promoting the invasion and me-tastasis of hepatocellular carcinoma cells as well as in VEGF-targeted anti-angiogenesis therapy for patients with HCC, aiming to provide some novel ideas to delay the disease progression in the patients.
