Characteristics of antibiotic resistance in group A Streptococcus strains isolated from children with scarlet fever
10.3760/cma.j.issn.0254-5101.2019.01.006
- VernacularTitle:猩红热患儿A组链球菌耐药特征的研究
- Author:
Jieying YIN
1
;
Wei ZHANG
;
Dongjing YANG
;
Xiaochun DONG
;
Lin LI
Author Information
1. 天津市疾病预防控制中心传染病科 300011
- Keywords:
Scarlet fever;
Group A Streptococcus;
Antibiotic resistance
- From:
Chinese Journal of Microbiology and Immunology
2019;39(1):30-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of antibiotic resistance in group A Streptococ-cus ( GAS) strains isolated from children with scarlet fever in Tianjin in order to provide reference for clinical drug administration. -ethods GAS strains were collected from 2011 to 2016. A total of 276 isolates were analyzed by antibiotic susceptibility test and emm typing. Results All of the isolates were susceptible to penicillin, cefazolin and vancomycin, while 98. 2％ were susceptible to both chloramphenicol and levofloxa-cin. The resistance rates to azithromycin, erythromycin, clarithromycin, clindamycin and tetracycline were 97. 8％, 97. 1％, 94. 2％, 94. 2％ and 79. 3％. The concomitant resistance to erythromycin, azithromycin, clarithromycin, clindamycin and tetracycline was 73. 2％. The resistance rates of GAS strains isolated from different years to tetracycline, clindamycin, clarithromycin, erythromycin and azithromycin were significantly different. A statistically significant difference was found between the percentages of emm12 and emm1 strains resistant to tetracycline (84. 0％ vs 59. 5％, χ2=13. 820, P=0. 000). Conclusions The isolated GAS strains are sensitive toβ-lactams and highly resistant to macrolide antibiotics, clindamycin and tetracycline. Penicillin remains the preferred treatment for GAS infection and cephalosporins may be used as a substitute if the patient is allergic to penicillin.
