Repeated transcranial magnetic stimulation for treating the negative symptoms of schizophrenia
10.3760/cma.j.issn.0254-1424.2019.03.009
- VernacularTitle:重复经颅磁刺激治疗慢性精神分裂症阴性症状的疗效研究
- Author:
Wenzhen TU
1
;
Xiaodong LIN
;
Ce CHEN
;
Xingshi CHEN
;
Zhiguang LIN
;
Mingdao ZHANG
;
Rongqing WU
Author Information
1. 温州市第七人民医院老年精神科
- Keywords:
Schizophrenia;
Transcranial magnetic stimulation;
Event-related potentials
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2019;41(3):202-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the negative symptoms of chronic schizophrenia and on the P300 component of schizophrenics' event-related potentials (ERPs).Methods Ninety convalescing schizophrenia patients were randomly divided into a 5 Hz group,a 10 Hz group and a 15 Hz group,each of 30.The three groups were treated with the corresponding 5 Hz,10 Hz or 15 Hz rTMS once a day,five times a week for five consecutive weeks.The P300 ERPs of all three groups were tested before and after the treatment.Any curative effect was evaluated using the scale for the assessment of negative symptoms (SANS).Results After the treatment,the average SANS score of the 10 Hz group was significantly different from that before the treatment and also from those of the other two groups after the treatment.After the treatment,significant improvement was also observed in the amplitude of P300 in the 10 Hz group.The treatment's effectiveness was negatively correlated with age and longer course of the disease.Conelusion rTMS at 10 Hz is the most effective of the protocols tested for improving the negative symptoms of schizophrenia and improving cognitive functioning.
