Anatomical partial splenectomy simutaneous with liver transplantation in pediatric patients for prevention of postoperative refractory hypersplenism
10.3760/cma.j.issn.0254-1785.2019.01.008
- VernacularTitle:儿童肝移植术中解剖性脾部分切除预防术后顽固性脾功能亢进
- Author:
Lin WEI
1
;
Zhijun ZHU
;
Wei QU
;
Zhigui ZENG
;
Haiming ZHANG
;
Liying SUN
;
Ying LIU
;
Guangpeng ZHOU
;
Zhongtao ZHANG
Author Information
1. 首都医科大学附属北京友谊医院肝脏移植中心
- Keywords:
Liver transplantation;
Hypersplenism;
Splenectomy
- From:
Chinese Journal of Organ Transplantation
2019;40(1):31-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and effectiveness of anatomical partial splenectomy during liver transplantation in pediatric patients to prevent postoperative refractory hypersplenism.Methods From January 2015 to August 2018,7 pediatric patients with preoperative severe hypersplenism underwent anatomical subtotal splenectomy together with liver transplantation at our institution.Clinical informations,including operative time,intraoperative bleedinh,postoperative hospital stay,postoperative complications,platelet counts,leukocyte counts and the length and thickness of spleen determined by abdominal ultrasound,were collected retrospectively and statistically analyzed.Results The median total operation time was 495 min (320-768 min),the median intraoperative blood loss was 350 mL (300-1300 mL) and the median hospital stay was 19 days (14-55 days).Patients were followed up for 7.0-36.6 months (median 20.1 months).The length and thickness of spleen were reduced immediately from (18.89 ± 1.77) to (11.13 ± 2.28) cm (P＜0.001)and from (6.31 ± 0.53) to (4.97 ± 1.29) cm (P＜0.05),respectively.During the follow-up period of the first week,the mean platelet counts and leukocyte counts increased from (46.71 ± 18.91) × 109/L to (173.71 ± 73.15) × 109/L (P＜0.001) and from (1.59 ± 0.42) × 109/L to (11.12 ± 4.17) × 109/L (P＜0.001),respectively.During the one-year follow-up period,there was no residual splenic regrowth,and the peripheral blood cell counts remained normal.All patients survived to date with no procedure-related complications.Conclusions The anatomical subtotal splenectomy during liver transplantation in pediatric transplant recipients with preoperative severe splenomegaly and hypersplenism is a feasible option for the prevention of posttransplant refractory hypersplenism.
