Living donor liver transplantations for pediatric patients withbiliary atresia in a single center: 306
10.3760/cma.j.issn.0254-1785.2019.01.004
- VernacularTitle:亲属活体肝移植治疗儿童胆道闭锁306例临床分析
- Author:
Wei GAO
1
;
Kai WANG
;
Nan MA
;
Chong DONG
;
Chao SUN
;
Xingchu MENG
;
Wei ZHANG
;
Bin WU
;
Hong QIN
;
Chao HAN
;
Yang YANG
;
Zhuolun SONG
;
Zhongyang SHEN
Author Information
1. 天津市第一中心医院移植外科天津市器官移植重点实验室 天津市器官移植临床医学研究中心 300192
- Keywords:
Liver transplantation;
Biliary atresia;
Survival rate
- From:
Chinese Journal of Organ Transplantation
2019;40(1):13-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical efficacy and prognosis of living donor liver transplantation (LDLT) in children with biliary atresia (BA).Methods The clinical data of 306 cases of BA patients who received LDLT from June 2013 to December 2017 in the Department of Pediatric Liver Transplantation of Tianjin First Center Hospital were retrospectively analyzed.The incidence of post-LDLT complications was summarized and different factors influencing long-term survival of the recipients were analyzed.Results The median age of recipients at transplantation was 7 (6,9) months,and 88.9％ of the recipients received left lateral lobes.The surgical-related complications mainly included lymphatic leakage (30.7％),bile duct stricture (7.8％) and portal vein stenosis (6.9％).The non-surgical-related complications were mainly EBV infection (57.8％) and CMV infection (36.6％).The incidence of pulmonary infection and acute rejection was 18.6％ and 13.7％,respectively.The 1-,3-,and 5-year survival rates of recipients and grafts were 97.2％,97.2％,97.2％ and 97.2％,96.4％,and 94.6％,respectively.A total number of 8 patients died after LDLT,mainly due to the complications of cardio-pulmonary system.Two patients underwent retransplantation due to graft dysfunction caused by antibody-mediated rejection.Recipient age,PELD scores,GRWR,previous surgical history and matching of ABO blood group between donors and recipients did not affect the long-term survival rates of recipients (P＞0.05).Conclusions Children with biliary atresia who received LDLT can obtain satisfactory clinical results.
