Clinical application of donor kidney in rhabdomyolysis combined with acute kidney injury
10.3760/cma.j.issn.0254-1785.2018.11.005
- VernacularTitle:横纹肌溶解症合并急性肾损伤供肾的临床应用
- Author:
Jianli WANG
1
;
Zhaojie GUAN
;
Lihua YIN
;
Lili ZHANG
;
Lei QIAN
;
Jie LIU
;
Yujian NIU
;
Zhongyang SHEN
Author Information
1. 解放军总医院第三医学中心器官移植研究所
- Keywords:
Kidney transplantation;
Donor;
Rhabdomyolysis;
Acute kidney injury
- From:
Chinese Journal of Organ Transplantation
2018;39(11):660-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of donor kidneys in rhabdomyolysis(RM) combined with acute kidney injury(AKI).Methods A retrospective analysis was made on the clinical data of 10 donors with RM and 14 cases of renal transplantation from March 2017 to May 2018.Results AKI was caused by RM in 10 donors.Before harvesting the donor kidneys,blood creatine kinase (CK) level was (14 005.19 ± 11 894.27) U/L in 10 donors,plasma myoglobin level was ＞3 000 μg/L in 7 cases,and that was (2 288 ± 680) μg/L in 3 cases.LDH level was 883 ± 453 IU/L and serum creatinine (Cr) value was (216.55 ± 125) μmol/L.6 donors received continuous renal replacement therapy.Six patients with delayed renal function recovery (DGF) were treated with CRRT.The duration of GDF was 3-20 days,with an average of 10 ± 6.6 days.All the patients were followed up for 3-15 months.The glomerular filtration rate was (40.19 ± 19.55) ml·min· 1.73 m-2 and (55.01 ± 15.94) ml · min· 1.73 m-2 at 1st and 3rd month after operation,respectively.Conclusion The incidence of DGF in donor kidneys with RM and AKI is high,and the short-term effect is satisfactory.The long-term effect needs to be further observed.
