Analysis of mismatch repair status in relation to clinicopathological characteristics and prognosis in colon cancer
10.3760/cma.j.issn.1007-631X.2019.04.017
- VernacularTitle:结肠癌组织中错配修复蛋白表达及其对患者预后的影响
- Author:
Chao WANG
1
;
Zhidong GAO
;
Kewei JIANG
;
Xiaodong YANG
;
Bin LIANG
;
Zhanlong SHEN
;
Kai SHEN
;
Peng GUO
;
Jian CAO
;
Yancheng CUI
;
Mujun YING
;
Shan WANG
;
Yingjiang YE
Author Information
1. 北京大学人民医院胃肠外科 北京大学人民医院外科肿瘤实验室 北京市结直肠癌诊疗研究重点实验室 100044
- Keywords:
Colonic neoplasms;
Prognosis;
Mismatch repair
- From:
Chinese Journal of General Surgery
2019;34(4):349-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of mismatch repair status on clinicopathological characteristics and prognosis in patients with colon cancer.Methods Patients who underwent radical excision for colon cancer between Nov 2012 and Mar 2016 at Peking University People's Hospital were enrolled.Clinicopathological data and prognosis were collected.Multivariate analysis were used to identify independent characteristics of MMR-deficient colon cancer.The influence of MMR-deficient on prognosis of colon cancer were analyzed through Kaplan-Meier curve.Results The overall rate of MMR-deficient in colon cancer was 17.1％ (51/299).Multivariate logistic regression analysis showed that low differentiation (OR =3.555,95％ CI:1.685-7.640,P ＜ 0.001),right-sided colon cancer (OR =5.645,95％ CI:2.483-14.715,P ＜ 0.001) and UICC Stage Ⅰ-Ⅱ (OR =4.099,95％ CI:1.863-9.840,P ＜0.001) were associated with MMR-deficient colon cancer.Conclusion Low differentiation,right-sided colon cancer and UICC Stage Ⅰ-Ⅱ were more common in MMR-deficient colon cancer.
