Effect of breast invasive ductal carcinoma with extensive intraductal components on local recurrence after breast conserving surgery
10.3760/cma.j.issn.1007-631X.2019.04.015
- VernacularTitle:乳腺浸润性导管癌伴广泛导管内癌成分对保乳术后局部复发的影响
- Author:
Yuxin MEI
1
;
Ya ZHOU
;
Hanqing ZOU
;
Rui YIN
;
Lei HUANG
;
Enhao WU
;
Guangyuan TANG
;
Xun ZHU
Author Information
1. 苏州大学附属第二医院普外科
- Keywords:
Breast neoplasms;
Prognosis;
Breast-conserving surgery;
Extensive intraductal component
- From:
Chinese Journal of General Surgery
2019;34(4):340-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinicopathological features and prognostic factors of patients with breast invasive ductal carcinoma with extensive intraductal components (EIC).Methods The clinical data of 182 patients of early breast invasive ductal carcinoma undergoing breast-conserving surgery were analyzed retrospectively in the Second Affiliated Hospital of Soochow University,and the clinicopathological features and prognosis of two groups of breast cancer patients with EIC positive (n =23) and EIC negative (n =159) were compared.Results In the EIC positive group,ipsilateral breast tumor recurrence (IBTR) was 21.7％ (5/23) and the distant metastasis rate was 4.3％ (1/23);in the EIC negative group,ipsilateral breast tumor recurrence (IBTR) was 1.9％ (3/159) and the distant metastasis rate was 3.8％ (6/159).The Kaplan-Meier curve showed that the 5-year local recurrence-free survival rates in the EIC positive group was lower than that of the EIC negative group (78％ vs.97.7％) (P ＜ 0.001),and the difference was statistically significant,but the 5-year distant metastasis-free survival rates in the two groups was similar (95.7％ vs.96.2％) (P =0.892).COX multivariate analysis showed that EIC was an independent risk factor for local recurrence after breast-conserving surgery in breast invasive ductal carcinoma patients.Conclusions EIC increases the local recurrence rate in patients with breast invasive ductal carcinoma undergoing breast-conserving surgery.
