Preoperative GGT, ALT/AST relates to clinicopathological features and prognosis after radical surgery for hepatocellular carcinoma

VernacularTitle:肝癌根治术前GGT、ALT/AST和术后临床病理特征与预后的关系
Author: Jie ZHAO ¹ ; Haibo YU ; Yunhai ZHU ; Feng CAI ; Xingchang HE
Author Information

1. 商丘市第一人民医院胃肠肝胆外科
Keywords: Carcinoma,hepatocellular; gamma-Glutamyltransferase; Tramsaminases; Prognosis
From: Chinese Journal of General Surgery 2019;34(4):328-331
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between preoperative GGT γ-glutamyl transferase),ALT/AST with clinicopathological features and prognosis after radical surgery of hepatocellular carcinoma(HCC).Methods The clinical data of 187 HCC patients undergoing radical resection in our hospital were retrospectively analyzed.Survival analysis was performed using the Kaplan-Meier analysis method to estimate the survival rate,and Log-rank analysis was used to compare survival rates between groups.Cox proportional hazards model was used for univariate and multivariate survival analysis.Results The Kaplan-Meier curves showed that HCC patients with normal GGT leval and higher ALT/AST ratio had a longer survival time than those with higher GGT leval and those with lower ALT/AST ratio (all P ＜ 0.05).The multivariate analyses showed that GGT leval and TNM staging were independent factors in predicting overall survival time in HCC patients.Conclusions GGT is a predictive index of overall survival of HCC patients.