Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognosis indicator for gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2019.04.008
- VernacularTitle:中性粒细胞与淋巴细胞比值联合纤维蛋白原检测对胃肠道间质瘤预后的判断价值
- Author:
Chenmin YE
1
;
Yongdong YI
;
Leibin SHEN
;
Guojun XIA
;
Chengyang YU
;
Fuyang TU
;
Zhiqiang ZHENG
Author Information
1. 温州医科大学附属第二医院育英儿童医院胃肠外科
- Keywords:
Gastrointestinal stromal tumors;
Fibrinogen;
Granulocytes;
Lymphocytes;
Prognosis
- From:
Chinese Journal of General Surgery
2019;34(4):319-322
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate FIB-NLR,a combined neutrophil-lymphocyte ratio (NLR) and fibrinogen concentration (FIB) in predicting the prognosis of gastrointestinal stromal tumors (GIST).Methods Data of 79 GIST patients who underwent surgery from Jun 2010 to Dec 2014 were retrospectively analyzed.Patients were divided into 3 groups:NLR ＜ 2.30 and FIB ＜ 3.85 g/L were defined as group 0,NLR≥2.30 and FIB ＜3.85 g/L or NLR ＜2.30 and FIB≥3.85 g/L as group 1,NLR≥2.30 and FIB≥3.85 g/L as group 2.The clinicopathological features of the three groups and the 5-year recurrence-free survival rate after surgery were compared.Results FIB concentration and NLR were significantly correlated with NIH risk grade and tumor size in GIST patients (x2 =9.517,12.41 1,6.081,20.067,all P ＜ 0.05).FIB-NLR was closely related to tumor size,tumor risk and tumor mitosis (x2 =14.406,12.514,28.225,all P ＜ 0.05).Survival analysis showed that high FIB predicts lower 5-year recurrence-free survival rate,it was 87.4％ for group 0,60.8％ for group 1,21.1％ for group2,x2 =29.617,P＜0.000).Conclusion FIB-NLR independently predicts the prognosis of gastrointestinal stromal tumors.
