Risk factors of lymph node metastasis and prognosis in early stage Ⅱ and Ⅲ gastroesophageal junctional adenocarcinoma
10.3760/cma.j.issn.1007-631X.2019.04.004
- VernacularTitle:早期Ⅱ型和Ⅲ型胃食管结合部腺癌淋巴结转移的危险因素及预后分析
- Author:
Jing JIN
1
;
Juan XIONG
Author Information
1. 浙江省衢州市人民医院普外科 324000
- Keywords:
Adenocarcinoma;
Esophagogastric junction;
Lymphatic metastasis;
Prognosis
- From:
Chinese Journal of General Surgery
2019;34(4):302-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors affecting early stage Ⅱ and Ⅲ gastroesophageal junctional adenocarcinoma lymph node metastasis,and to explore the impact of lymph node metastasis on prognosis.Methods From Jan 2007 to Jan 2014,220 early stage Ⅱ/Ⅲ gastroesophageal junction adenocarcinoma cases underwent radical resection and were followed-up.Kaplan-Meier analysis was made on lymph node metastasis in relation with patient prognosis.Results Lymph node metastasis rate was 13.1％ in the early stage Ⅱ and Ⅲl gastroesophageal junction adenocarcinoma,tumor diameter ≥2 cm,undifferentiated type and infiltrating submucosa were independent risk factors for early stage Ⅱ/Ⅲ AEG lymph node metastasis.The l-year overall survival rates of patients with early stage Ⅱ / Ⅲ AGE lymph node metastasis and without lymph node metastasis were 93.1％ (27/29) and 98.4％ (188/191),P =0.130.The 3-year overall survival rates of the lymph node metastasis group and without lymph node metastasis group were65.5％ (19/29) and 91.6％ (175/191),respectively.(P=0.000).Conclusion Patients with early stage Ⅱ and Ⅲ gastroesophageal junctional adenocarcinoma with tumor diameter ≥ 2 cm,undifferentiated and infiltrating submucosa have a higher risk of lymph node metastasis,which is related to poor prognosis.
