Risk factors for early recurrence and metastasis in BCLC A hepatocellular carcinoma patients after hepatectomy
10.3760/cma.j.issn.1007-631X.2019.02.001
- VernacularTitle:乙肝相关性巴塞罗那A期肝细胞癌术后早期复发转移的危险因素分析
- Author:
Xianmao SHI
1
;
Jie CHEN
;
Rongyun MAI
;
Zhongrong LONG
;
Jinwu LIU
;
Xuemei YOU
;
Feixiang WU
;
Lequn LI
Author Information
1. 广西医科大学附属肿瘤医院肝胆外科
- Keywords:
Carcinoma;
hepatocellular;
Hepatectomy;
Neoplasm recurrence;
local
- From:
Chinese Journal of General Surgery
2019;34(2):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of postoperative recurrence and metastasis of of BCLC stage A (BCLC-A) hepatocellular carcinoma (HCC).Methods Data of 210 cases of liver resection for HCC were retrospectively analyzed from Nov 2013 to June 2016.Multivariate logistic regression analysis was used to analyze the risk factors for postoperative recurrence.The cumulative survival rates were calculated using the Kaplan-Meier method and the diffrences of the related factors between various groups were analyzed by Log-rank test.Results Univariate analysis showed that alpha-fetoprotein (AFP),neutrophil-lymphocyte ratio (NLR),hepatitis B virus surface antigen (HBsAg) positive and intraoperative transfusion were associated with early recurrence and metastasis after hepatectomy (P ＜ 0.05).Multivariate analysis showed that AFP ＞ 400 ng/ml is an independent risk factor for early postoperative recurrence and metastasis (P =0.008).HBV DNA positive can affect the disease-free survival rate after HCC resection (P =0.030).Conclusion AFP is an independent risk factor for early postoperative recurrence and metastasis.Preoperative HBV DNA positive significantly decreases the disease-free survival rate in HCC patients.
