NF-κB signaling pathway in psoriasis
10.3760/cma.j.issn.0412-4030.2019.05.019
- VernacularTitle:核因子κB信号通路在银屑病中的研究进展
- Author:
Jiaxu PAN
1
;
Jing ZHOU
Author Information
1. 哈尔滨医科大学附属第二医院皮肤性病科 150000
- Keywords:
Psoriasis;
NF-kappa B;
Transcription factor RelA;
Cell proliferation;
Apoptosis;
IκBα
- From:
Chinese Journal of Dermatology
2019;52(5):361-363
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor (NF)-κB,a kind of protein transcription factor,mediates inflammation and other complex biological processes,and is a key regulator of many immune and inflammatory pathways,cell proliferation,differentiation and apoptosis.Psoriasis is an inflammatory skin disease characterized by increased levels of phosphorylated NF-κB,which leads to an increase in anti-apoptotic activity of keratinocytes and aggravation of inflammatory reactions.This review summarizes advances in NF-κB signaling pathway and its role in psoriasis.
