Cellular senescence-mediated skin aging
10.3760/cma.j.issn.0412-4030.2019.03.015
- VernacularTitle:细胞老化介导皮肤衰老的研究进展
- Author:
Wenjie LIU
1
;
Min JIANG
;
Leihong XIANG
Author Information
1. 复旦大学附属华山医院皮肤科上海市皮肤病研究所 200040
- Keywords:
Skin aging;
Cell aging;
Senescence-associated secretory phenotype
- From:
Chinese Journal of Dermatology
2019;52(3):211-214
- CountryChina
- Language:Chinese
-
Abstract:
Aging is age-related degeneration of the whole body,and skin aging is one of the most visualized changes in aging.Cellular senescence is a stress response to stable cell cycle arrest,and it is both the hallmark of aging and the important mechanism of the occurrence and development of aging.With the development of skin aging,senescent cells gradually accumulate in both the epidermis and dennis,and further exacerbate aging.Thus,when these senescent cells are eliminated,the aging skin seems to be rejuvenated.Cellular senescence is involved in the process of skin aging,which may be related to activation of DNA damage response pathway,up-regulation of regulatory proteins blocking cell cycle,and increase of senescence-associated secretory phenotypes.Cellular senescence is expected to be a novel target for preventing skin aging in the future.
