The role of neuropsychiatric factors in the occurrence of psoriasis
10.3760/cma.j.issn.0412-4030.2019.03.013
- VernacularTitle:精神神经因素在银屑病发病中的作用
- Author:
Yimeng GAO
1
;
Hongzhong JIN
Author Information
1. 中国医学科学院北京协和医学院北京协和医院皮肤科 100730
- Keywords:
Psoriasis;
Anxiety;
Stress,psychological;
Neuropeptides;
Nerve growth factors;
Hypothalamic-pituitary-adrenocortical axis;
Sympathetic-adrenal medullary system
- From:
Chinese Journal of Dermatology
2019;52(3):204-207
- CountryChina
- Language:Chinese
-
Abstract:
Considerable evidence has indicated that psychological factors,such as anxiety,nervousness and mental stress,can induce or exacerbate psoriasis and affect therapeutic effects to a certain degree,suggesting that psychological factors may play an important role in the occurrence of psoriasis.Current researches on neuropsychiatry-related pathogenesis of psoriasis mainly include two aspects:on the one hand,acting as stressors,psychological factors can activate the following two neuroendocrine systems,including hypothalamic-pituitary-adrenocortical axis and sympathetic-adrenal medullary system;on the other hand,neuropeptides and nerve growth factors induce in vivo neurogenic inflammation.Neuropsychiatric factors may participate in the occurrence of psoriasis through the above pathways.
