Can urine albumin/creatinine ratio replace 24 hours urinary albumin?
10.3760/cma.j.issn.0578-1426.2019.05.009
- VernacularTitle:尿白蛋白/肌酐比值可以完全替代24小时尿微量白蛋白吗?
- Author:
Ran LIU
1
;
Hong ZHU
;
Juhong YANG
;
Zhongai GAO
;
Xinxin YUAN
;
Xiaochen LI
;
Jingyu WANG
;
Baocheng CHANG
Author Information
1. 国家卫生健康委员会激素与发育重点实验室 天津市代谢性疾病重点实验室 天津医科大学代谢病医院内分泌研究所 300070
- Keywords:
Diabetes mellitus,type 2;
Urine albumin/urine creatinine ratio;
24 h Urine microalbumin quantity
- From:
Chinese Journal of Internal Medicine
2019;58(5):377-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between urinary albumin/creatinine ratio (ACR) and 24-hour urinary microalbumin (UMA) and evaluate the predictive value of ARC for early diabetic nephropathy.Methods A total of 368 patients with type 2 diabetes mellitus were retrospectively collected.Early diabetic nephropathy was defined as 24h UMA 30～＜300 mg/24h.The correlation between ACR and 24hUMA,and the area under the receiver operating characteristic (ROC) curve of ACR in diagnosis of early diabetic nephropathy were calculated.Gender,age,course of disease,fasting venous blood glucose,glycosylated hemoglobin,blood pressure,triglyceride and total cholesterol were used as adjusting variables to establish univariate and multivariate logistic models of ACR for early diabetic nephropathy,respectively.A regression model was used to evaluate the diagnostic value of ACR for early diabetic nephropathy.Results The correlation between ACR and 24h UMA was 0.658.The area under ROC curve of ACR for early diabetic nephropathy was 0.907 before and 0.933 after adjustments of gender,age,course of disease,fasting venous blood glucose,glycosylated hemoglobin,blood pressure,triglyceride and total cholesterol,respectively.The OR value of ACR of diabetic nephropathy was 2.016 before and 2.762 after same adjustments.The calibration of Hosmer-Lemeshow chi-square test evaluation model was 19.362 before (P=0.13) and 14.928 after adjustments (P=0.061).Conclusion ACR is a better predictor for early diabetic nephropathy although its value is influenced by gender,age,course of disease,blood sugar,lipid,and blood pressure.
