Study on the effect of calorie restriction induced weight loss on the thyroid function in patients with metabolic syndrome
10.3760/cma.j.issn.1000-6699.2019.03.006
- VernacularTitle:甲状腺功能在代谢综合征患者限食减重后的变化
- Author:
Xiaogai ZHANG
1
;
Guofang CHEN
;
Shuhang XU
;
Chao LIU
Author Information
1. 南京中医药大学附属中西医结合医院
- Keywords:
Calorie restriction;
Thyroid function;
Metabolic syndrome
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(3):213-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of short-term very low calorie diet on the thyroid function in patients with metabolic syndrome.Method Fifty-nine patients [(23 males and 36 females,average age (38.17 ± 9.61) years] with metabolic syndrome were received very low calorie diet for 9 days in our hospital.Anthropometric and biochemical parameters were determined before and after very low calorie diet.The level of serum FT3,FT4,TSH was measured by chemiluminescent assay,and the level of serum reverse triiodothyronine (rT3) was measured by radioimmunoassay in 31 cases.Homeostasis model assessment for insulin resistance (HOMA-IR) was employed to evaluate the severity of insulin sensitivity.Results After short-term very low calorie diet,the average body weight decreased from (76.30± 19.61)kg to (71.97 ± 18.58)kg (P＜0.01);waist circumference reduced by 6.98 cm (P＜ 0.01).The blood pressure,total cholesterol,triglycerides,low density lipoprotein-cholesterol,fasting blood glucose,fasting insulin,and HOMA-IR were all reduced significantly after very low calorie diet.The serum FT3 level decreased from (5.09 ± 0.58) pmol/L to (4.52 ± 0.58) pmol/L (P＜0.01).The changes of FT4,TSH,and rT3 were without difference.The basal FT3 levels were positively correlated with basal body weight,body mass index,waist circumference (r =0.335,0.297,and 0.262 respectively,all P＜ 0.05),and negatively correlated with HbAIC,fasting blood glucose (r=-0.293,-0.268,both P＜0.05).The basal FT4 level was negatively correlated with basal fasting insulin,HOMA-IR (r =-0.284,-0.330,both P＜0.05),while the basal TSH level was positively correlated with fasting insulin and HOMA-IR (r=0.381,0.281,both P＜0.05).The basal body weight was positively correlated with waist circumference,fasting insulin,HOMA-IR,while negatively correlated with high density lipoproteincholesterol (HDL-C;r =0.899,0.382,0.305,-0.333,all P＜0.05).After very low calorie diet,there were no more significant correlations between FT3 changes and baseline body weights,waist circumferences,and fasting blood glucose levels.The variation amplitude of body weight was positively correlated with baseline weight,waist circumference,fasting insulin,HOMA-IR,and FT3 levels (r =0.564,0.494,0.307,0.245,0.384,all P＜ 0.05).Conclusions Short-term very low calorie diet decreases the serum FT3 level and improves metabolic markers in patients with metabolic syndrome.The serum FT3 level of patients with metabolic syndrome was positively associated with body weight,whereas negatively associated with HbAIC and fasting blood glucose.Moreover,FT4 level had negative correlation with HOMA-IR,but TSH level had positive correlation with HOMA-IR.Those who had higher body weights,FT3 and HOMA-IR levels,may have more profound decrease of body weight after very low calorie diet.
