Assessment of fracture risk in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2019.01.016
- VernacularTitle:2型糖尿病患者骨折风险的评估方法
- Author:
Jing MA
1
;
Lige SONG
Author Information
1. 同济大学附属同济医院内分泌代谢科
- Keywords:
Diabetes mellitus,type 2;
Fracture risk;
Evaluation;
Bone mineral density;
Bone microstructure
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(1):86-90
- CountryChina
- Language:Chinese
-
Abstract:
Fracture risk is higher in the patients with type 2 diabetes mellitus (T2DM) comparing to non-diabetic subjects,but bone mineral density (BMD) in type 2 diabetic patients may be increased,normal or decreased compared to non-diabetic population.Thus,BMD is not an accurate index for deciding to start antiosteoporotic treatment in type 2 diabetic patients with high fracture risk,and the more accurate assessment tools which can reflect the fracture risk in type 2 diabetic patients are needed.Studies have shown that the fracture risk in type 2 diabetic patients is increased with the decreasing of BMD,but the fracture usually happened with relative high BMD.Trabecular bone score is lower in type 2 diabetic patients than that in non-diabetic patients.High-resolution peripheral quantitative computed tomography (HR-pQCT) accurately reflects the bone microstructure of T2DM.FRAX may get more accurate fracture risk in type 2 diabetic patients by replacing rheumatoid arthritis with T2DM.DeFRA is a new algorithm derived from FRAX,which can evaluate fracture risk more accurately than FRAX in type 2 diabetic patients.Skeletal muscle mass is decreased in type 2 diabetic patients.Pentosidine,as one of advanced glycation end products,is related to the fracture risk in type 2 diabetic patients.Based on these data,this paper will review the assessments which may be used to evaluate the fracture risk in type 2 diabetic patients.
