Association of serum CMPF level with fatty acid metabolism and obesity in community population
10.3760/cma.j.issn.1000-6699.2019.01.008
- VernacularTitle:社区人群中血清CMPF水平与脂肪酸代谢及肥胖的相关性
- Author:
Jiarong DAI
1
;
Shan ZHANG
;
Peihong CHEN
;
Hua JIN
;
Jufen YI
;
Xinmiao XIE
;
Meili YANG
;
Ting GAO
;
Lili YANG
;
Xuemei YU
;
Xueli ZHANG
Author Information
1. 南方医科大学第三临床医学院
- Keywords:
3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid;
Obesity;
Triglycerides;
Free fatty acids
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum level of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF),a significant metabolite offish oil,in subjects with normal glucose tolerance (NGT) in local communities,and to investigate the association of CMPF with fatty acid metabolism.Methods A total of 272 NGT participants from screening for diabetes in Shanghai in 2013 were enrolled.Anthropometric measurements,biochemical evaluation,and questionnaire interview were performed for all the participants.The participants were divided into normal weight group [body mass index (BMI) ≤23.9 kg/m2,n =143] and overweight/obesity group (BMI ≥ 24 kg/m2,n =129).The serum CMPF concentrations were determined using an enzyme-linked immunosorbent assay.Results Serum CMPF level in overweight/obesity group was lower than that in normal weight group [96.50 (46.11,169.56) μmol/L vs 153.20 (83.16,282.97) μmol/L,P＜0.05].The serum CMPF level was negatively correlated with BMI (r =-0.256,P＜0.01),triglycerides (r =-0.175,P =0.004),and free fatty acid (r =-0.126,P =0.041) according to bivariate correlation analyses.A multivariate stepwise linear regression analysis showed that the serum CMPF level was independently associated with BMI,triglycerides,free fatty acid,and HbA1C.A logistic regression analysis showed that the CMPF was a protective factor against obesity (OR =0.324,95％ CI 0.158,0.664).Conclusion Serum CMPF level is reduced in overweight/obese subjects.CMPF is beneficial to lipid metabolism.
