Effect of transcutaneous electrical acupoint stimulation on intestinal mucosal injury in patients undergoing laparoscopic radical resection of colorectal cancer
10.3760/cma.j.issn.0254-1416.2019.01.013
- VernacularTitle:经皮穴位电刺激对全麻腹腔镜结直肠癌根治术患者术后肠粘膜损伤的影响
- Author:
Xueming FAN
1
;
Fangxiang ZHANG
;
Ling HUANG
;
Bingning CHEN
;
Weijing ZHANG
;
Jingchao ZHANG
Author Information
1. 贵州省人民医院麻醉科,贵阳550002
- Keywords:
Electric stimulation therapy;
Anesthesia,general;
Laparoscopy;
Intestinal mucosa
- From:
Chinese Journal of Anesthesiology
2019;39(1):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on intestinal mucosal injury in patients undergoing laparoscopic radical resection of colorectal cancer.Methods Fifty-six American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients,aged 35-64 yr,with body mass index of 18-25 kg/m2,scheduled for elective laparoscopic radical resection of colorectal cancer,were selected and divided into 2 groups (n =28 each) using a random number table method:general anesthesia group (group G) and TEAS combined with general anesthesia group (group TG).In group TG,patients received continuous TEAS at bilateral Neiguan,Hegu,Zusanli,Shangjuxu and Xiajuxu acupoints from 30 min before anesthesia induction until the end of surgery,with a frequency 2/100HZ,disperse dense waves,intensity the maximum current that could be tolerated (3-8 mA).After induction of anesthesia,the patients were endotracheally intubated and mechanically ventilated,and combined intravenous-inhalational anesthesia was used to maintain anesthesia in both groups.Peripheral venous blood samples were collected when entering the operating room (T1),at the end of operation (T2),and at 24 and 72 h after operation (T3,4) for determination of intestinal fatty acid binding protein (I-FABP) and diamine oxidase (DAO) in palsma using enzyme-linked immunosorbent assay.Quality of Recovery-9 (QoR9) was used to assess the postoperative quality of recovery at 24 h before surgery (T0),T3 and T4.Results The concentrations of plasma I-FABP and DAO were significantly higher at T2 and T3 than at T1 in G and TG groups (P＜0.05).Compared with the baseline at T0,QoR-9 scores were significantly decreased at T3 and T4 in G and TG groups (P＜0.05).Compared with group G,the concentrations of plasma I-FABP at T2-T4 and DAO at T2 and T3 were significantly decreased,and QoR-9 scores were increased at T3 and T4 in group TG (P＜0.05).Conclusion TEAS can attenuate intestinal mucosal injury in patients undergoing laparoscopic radical resection of colorectal cancer.
