Chromosomal changes in transitional cell carcinoma of the bladder.
- Author:
Heung Jae PARK
1
;
Duck Ki YOON
Author Information
1. Department of Urology, Korea University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
transitional cell carcinoma;
bladder;
cytogenetic analysis
- MeSH:
Carcinoma, Transitional Cell*;
Constitution and Bylaws;
Culture Techniques;
Cytogenetic Analysis;
Diploidy;
Disease Susceptibility;
Hand;
Recurrence;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Korean Journal of Urology
1992;33(3):418-423
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The chromosome constitution of 11 superficial and 2 invasive transitional cell carcinomas of the bladder has been examined by culture technique. Of the 11 superficial tumors, 6 (54.5%) had the modal number ranging in the diploid area (40-49 chromosomes) and 5 of them (83.5%) had no recurrence for more than 1 year. Six (54.5%) out of 11 superficial tumors had 1 to 3 marker chromosomes and only 2 (33.3%) of them recurred but 1 (20%) out of remaining 5 (no marker chromosome) superficial bladder tumors has recurred. On the other hand. all invasive transitional cell carcinomas of the bladder had hyperdiploid modes and marker chromosomes. Although the numbers of subject for this study are small we speculate that a large number of chromosomes and presence of marker chromosome might be correlated with aggressiveness of a particular tumor diathesis but the meaning of marker chromosome should be reevaluated. So in order to get the prognostic information chromosomal analysis should be thought combined with other prognostic factors.
