Investigation of relationship of serum and carcinoma levels of plasminogen activator inhibitor-1 with the invasion and metastasis of endometrial carcinoma
10.3760/cma.j.issn.0254-9026.2019.05.020
- VernacularTitle:纤溶酶原激活物抑制剂-1在子宫内膜癌患者中的表达
- Author:
Shuai HUANG
1
;
Ye LI
;
Qiubo LYU
;
Dan ZHOU
;
Qian HU
;
Zhiyuan SHANG
Author Information
1. 北京医院妇产科国家老年医学中心 100730
- Keywords:
Endometrial neoplasms;
Plasminogen activator inhibitor-1;
Endometrial hyperplasia
- From:
Chinese Journal of Geriatrics
2019;38(5):558-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of serum and carcinoma levels of plasminogen activator inhibitor-1 (PAI-1)with clinical characteristics in patients with endometrial carcinoma.Methods Serum level of PAI-1 was determined by using enzyme-linked immunosorbent assay(ELISA) in patients with endometrial carcinoma (n =40),uterine prolapsed with normal endometrial tissues(n=40).The protein expression of PAI-1 in endometrial tissue was detected by using immunohistochemistry in patients with endometrial carcinoma and uterine prolapse patients.Results Serum level of PAI-1 was higher in patients with endometrial carcinoma than in uterine prolapse patients with normal endometrial tissues(19.43±7.12 μg/L vs.6.58±2.33 μg/L,P＜0.05).The rate of positive expression of PAI-1 was higher in endometrial carcinoma tissue than in uterine prolapse tissue[62.5 ％ (25/40) vs.7.5 ％ (3/40),P ＜ 0.01].Compared with early-stage endometrial carcinoma,advanced endometrial carcinoma had an increased rate of positive expression of PAI-1 (P ＜0.01).Compared with endometrioid adenocarcinoma,other pathological types of endometrial carcinoma had an increased rate of positive expression of PAI-1 (P ＜ 0.05).Poorly differentiated endometrial carcinoma versus highly differentiated endometrial carcinoma had an increased positive rate of PAI-1 (P ＜0.05).The rate of positive expression of PAI-1 was higher in endometrial carcinoma with myometrial invasion than without myometrial invasion(25/31 vs.0/9,P＜0.01).Conclusions The expression level of PAI-1 may be related to the invasion and metastasis of endometrial carcinoma.
