Correlation between myeloperoxidase levels and adverse cardiac events in patients undergoing coronary stent implantation
10.3760/cma.j.issn.0254-9026.2019.05.015
- VernacularTitle:冠状动脉支架置人术患者外周血髓过氧化物酶水平与心脏不良事件的相关性
- Author:
Guoying GENG
1
;
Yujie ZHAO
;
Ning BA
;
Lei MAO
;
Lei WU
;
Wenshan CHEN
;
Hengliang LIU
Author Information
1. 郑州人民医院心血管内科
- Keywords:
Coronary disease;
Stents;
Peroxidase
- From:
Chinese Journal of Geriatrics
2019;38(5):533-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between myeloperoxidase(MPO)levels and adverse cardiac events in patients undergoing coronary stent implantation.Methods A total of 76 patients undergoing coronary stent implantation from January 2015 to June 2016 in the cardiac surgery department of our hospital were enrolled in this study.Serum levels of MPO,high sensitivity C-reactive protein(hs-CRP),and interleukin 6 (IL-6)were detected by enzyme-linked immunosorbent assays(ELISA).After a one-year follow-up,the receiver operating characteristic(ROC)curve was used to determine the predictive value of the difference in MPO before and after the operation(△MPO)on the long-term prognosis of patients after coronary stent implantation.The correlations of △MPO with the traditional risk factors for coronary heart disease and adverse cardiac events were analyzed using multi factor Logistic regression analysis.Results Serum levels of MPO,hs-CRP and IL 6 increased in patients after coronary stent implantation,compared with those before treatment (P ＜ 0.05).The results of ROC curve analysis showed that the area under the curve(AUC)value of serum △MPO was 0.786,the 95 ％ confidence interval was 0.471～ 1.000 and the predictive value of serum △MPO for adverse cardiac events was significant(P ＜0.05).There was a significant correlation between △MPO and age,and the incidence of adverse cardiac events increased with increased △MPO levels.Logistic regression analysis showed that serum △MPO levels could preliminarily diagnose the cardiovascular risk after coronary stent implantation and independently predict the occurrence of adverse cardiac events.Conclusions MPO levels in peripheral blood are notably elevated in patients after coronary stent implantation when compared with pre-treatment levels.Serum △MPO levels can preliminarily diagnose adverse cardiac events after coronary stent implantation and can be used as a marker to predict adverse cardiac events.
