Effects of perindopril on bone turnover markers and bone mineral density in osteoporotic rats
10.3760/cma.j.issn.0254-9026.2019.04.024
- VernacularTitle:培哚普利对骨质疏松大鼠骨转换指标及骨密度的影响
- Author:
Qing XUE
1
;
Yi ZHOU
;
Chuyu ZHONG
Author Information
1. 中山大学附属第五医院老年病科
- Keywords:
Perindopril;
Osteoporosis;
Bone density;
Alkaline phosphatase
- From:
Chinese Journal of Geriatrics
2019;38(4):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of peridopril on osteoporosis and possible mechanisms involved.Methods Fifty experimental rats were divided into a normal control group,a sham operation group(Sham group),an ovariectomized group(OVX group),a perindopril group and an estrogen group (E2 group),with ten in each group.The perindopril group was intragastrically administered perindopril 4 mg/kg per day,the E2 group was intragastrically administered estrogen 1.2 mg/kg per day,and rats in the normal control group,the sham group and the OVX group were intragastrically given an equal volume of distilled water.Drugs were given once a day for 12 weeks.After 12 weeks of drug intervention,all rats were anaesthetized and 12 ml blood was extracted from the heart,and serum calcium,phosphorus,alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase(TRACP) were determined by enzyme-linked immunosorbent assays.The bone mineral density(BMD)of the left femur was measured by dual energy X-ray absorptiometry.Results After 4 weeks of drug intervention,the femur BMD was lower in the OVX group than in the sham operation group and the normal control group(F =12.224,P＜0.05),and there was no difference between the sham operation group and the normal control group(P＞0.05).After 12 weeks of drug intervention,serum Ca and P levels had no significant difference between the groups(P＞0.05).ALP and TRACP levels in the OVX group were (192.30± 14.50) U/L and (12.7 ± 1.72) U/L,respectively,which were significantly higher than those in the sham operation group(P＜0.01).ALP and TRACP levels in the perindopril group were (169.00 ± 10.14) U/L and (10.19 ± 1.24) U/L,respectively,which were lower than those in the OVX group(P＜0.05).ALP and TRACP levels in the E2 group were (130.76±9.47) U/L and (7.04±0.96) U/L,respectively,which were lower than those in the OVX group(P＜0.01).BMD in the OVX group was (0.161±0.011) g/cm2,which was lower than that in the sham operation group (P ＜ 0.01).BMD in the perindopril group was (0.173 ± 0.011) g/cm2,which was higher than that in the OVX group(P ＜0.05).After estrogen treatment,BMD of the E2 group was (0.196±0.008) g/cm2,which was higher than that in the OVX group(P ＜0.01).Conclusions Perindopril can decrease high bone turnover,increase bone density in ovariectomized rats,and thus may be used for alleviating postmenopausal osteoporosis.
