Research progress on lamin and Hutchinson-Gilford progeria syndrome
10.3760/cma.j.issn.0254-9026.2019.03.027
- VernacularTitle:核纤层蛋白与Hutchinson-Gilford早老症的研究进展
- Author:
Tianwei XIA
1
;
Fang WANG
;
Guowei ZHOU
;
Chao ZHANG
;
Qing JIANG
;
Jirong SHEN
Author Information
1. 南京中医药大学附属医院 210023
- Keywords:
Aging;
Lamin;
Hutchinson-Gilford progeria syndrome
- From:
Chinese Journal of Geriatrics
2019;38(3):336-340
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have shown that abnormal expression and modification of lamin are closely related to aging.Hutchinson-Gilford progeria syndrome(HGPS)is a rare and severe premature aging disease caused by mutations in the gene encoding nuclear envelope proteins of A-type lamins (LMNA).The pathogenesis of HGPS is similar to the aging process of normal individuals,thus research on HGPS will be helpful for understanding the mechanisms of senescence and developing antiaging drugs.This paper reviews recent advances in lamin and the pathogenesis and treatment of HGPS,in order to provide a reference for further basic and clinical research on HGPS.
