Distribution and antimicrobial resistance profile of clinical bacterial isolates from blood culture in China, 2014-2015
10.3760/cma.j.issn.1674-2397.2019.01.005
- VernacularTitle:2014至2015年全国血流感染细菌耐药监测报告
- Author:
Yunbo CHEN
1
;
Jinru JI
;
Chaoqun YING
;
Ying HUANG
;
Jilu SHEN
;
Hui DING
;
Jinwei HUANG
;
Yuanyuan DAI
;
Yongyun LIU
;
Liping ZHANG
;
Liang GUO
;
Baohua ZHANG
;
Yanhong LI
;
Haifeng MAO
;
Li WANG
;
Lin ZHENG
;
Beiqing GU
;
Haixin DONG
;
Chuandan WAN
;
Zhixiang LIAO
;
Rong XU
;
Shuyan HU
;
Li SUN
;
Shucun ZHANG
;
Lan MA
;
Bo QUAN
;
Jianzhong WANG
;
Zhenghai YANG
;
Wencheng ZHU
;
Fei DU
;
Dengyan QIAO
;
Xiusan XIA
;
Lanjuan LI
;
Yonghong XIAO
Author Information
1. 浙江大学医学院附属第一医院传染病诊治国家重点实验室
- Keywords:
Gram-negative bacteria;
Gram-positive bacteria;
Drug resistance,bacterial;
Bloodstream infection;
Resistance surveillance;
Microbial sensitivity tests
- From:
Chinese Journal of Clinical Infectious Diseases
2019;12(1):24-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution and antimicrobial resistance profile of clinical bacterial strains isolated from blood culture in China.Methods Clinical bacterial strains isolated from blood culture from participating hospitals of Blood Bacterial Resistance Investigation Collaborative System (BRICS) during January 2014 to December 2015 were collected.Antibiotic susceptibility tests were conducted with agar dilution or broth dilution methods as recommended by US Clinical and Laboratory Standards Institute(CLSI)2018.The data were analyzed with Whonet 5.6 software.Results During the study period,4 801 clinical bacterial isolates were collected from 26 hospitals,of which 1 798 (37.5％) were Gram-positive bacteria and 3 003 (62.5％) were gram-negative bacteria.The top 10 isolates were Escherichia coli (33.8％),coagulase-negative Staphylococcus (19.0％),Klebsiella pneumoniae (11.9％),Staphylococcus aureus (10.1％),Acinetobacter baumannii (4.0％),Pseudomonas aeruginosa (3.8％),Streptococcus (3.0％),Enterobacter sulcus (2.9％),Enterococcus faecium (2.8％) and Enterococcus faecalis (1.8％).Methicillin-resistant Staphylococcus aureus (MRSA) and methicillinresistant coagulase-negative Staphylococcus (MRCNS) accounted for 33.9％ (165/487) and 56.9％ (520/913) of Staphylococcus aureus and coagulase-negative Staphylococcus respectively.No vancomycinresistant Staphylococcus was detected.The resistance rate of Enterococcus faecium to vancomycin was 0.7％ (1/135),and no vancomycin-resistant Enterococcus faecaliss was detected.The positive rates of extendedspectrum β-1actamases(ESBLs)-producing Escherichia coli,Klebsiella pneumoniae and Proteus were 56.9％ (923/1 621),30.1％ (172/572) and 29.2％ (7/24),respectively.The positive rates of carbapenemresistant Escherichia coli,Klebsiella pneumoniae,Enterobacter,Salmonella and Citrobacter were 1.2％ (20/1 621),7.2％ (41/572),4.3％ (6/141),1.5％ (1/67) and 2.9％ (1/34),respectively.The resistance rates of Acinetobacter baumannii to polymyxin and tegacycline were 2.6％ (5/190) and 8.9％ (17/190)respectively,and that of Pseudomonas aeruginosa to polymyxin and fosfomycin were 1.1％ (2/183)and 0.6％ (1/183),respectively.Conclusions The surveillance results from 2014 to 2015 show that the main pathogens of blood stream infection in China are Gram-negative bacteria,while Escherichia coli is the most common pathogen,the detection rate of MRSA is lower than other surveillance data in the same period in China;carbapenem-resistant Klebsiella pneumoniae and Escherichia coli are at a low level as shown in this surveillance.
