Research progress of lncRNA in the occurrence and metastasis of pancreatic cancer
10.3760/cma.j.issn.1007-8118.2019.04.021
- VernacularTitle:长链非编码RNA在胰腺癌发生和转移中的作用机制研究进展
- Author:
Yecheng WANG
1
;
Fei LI
Author Information
1. 首都医科大学宣武医院普通外科
- Keywords:
Pancreatic neoplasms;
RNA,messenger;
Signaling pathway;
Neoplasm metastasis;
Mechanism of action
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a malignant and gastrointestinal tumor.The five year survival for pancreatic cancer is very low.The pathogenic factors for pancreatic cancer are not yet clear.However,more and more studies have showed that lncRNAcontributed to pancreatic cancer proliferation and metastasis through genomic imprinting,chromatin modification,transcriptional activation and inhibition,nuclear transport,and protein function regulation.In recent years,with the continuous deepening of basic researches of pancreatic cancer,there were many long non-coding RNA deregulated in pancreatic cancer,which played an important role in tumororigenesis and metastasis.In this article,we reviewed the relevant researches on the mechanism of lncRNA in the occurrence and metastasis of pancreatic cancer.
