Pyroptosis and hepatic ischemia-reperfusion injury
10.3760/cma.j.issn.1007-8118.2019.03.019
- VernacularTitle:细胞焦亡与肝脏缺血再灌注损伤
- Author:
Baohong GU
1
;
Zedong FENG
;
Xuemei LI
;
Jike HU
;
Fan ZHANG
;
Chonghui LI
;
Hao CHEN
;
Jiahong DONG
Author Information
1. 兰州大学第二临床医学院 730030
- Keywords:
Reperfusion injury;
Liver;
Caspase-1;
Inflammasomes;
Pyroptosis
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(3):230-233
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a form of new programmed cell death which is dependent on Caspase-1 in recent years.When it' s stimulated by various dangerous signals from hepatic ischemia-reperfusion injury,the intracellular pattern recognition receptors are assembled into inflammasomes and Caspase-1 which was transformed into active form.Activated Caspase-1 promotes the maturation and secretion of pro-inflammatory cytokines IL-1β and IL-18,initiates the innate immunity rapidly and then induces severe inflammatory reaction.In addition,Caspase-1 can also cleave Gasdermin D and release its N-terminal domain triggering pyroptosis.Many studies showed that pyroptosis play a crucial role in hepatic ischemia-reperfusion injury.In this review,we discussed the activation mechanism and research progress of pyroptosis in hepatic ischemia-reperfusion injury.
