The expression of nuclear factor of activated T cells in hepatocellular carcinoma and its relationship with clinicopathologic factors
10.3760/cma.j.issn.1007-8118.2019.03.004
- VernacularTitle:活化T细胞核因子在肝细胞癌组织中的表达及与临床病理因素的关系
- Author:
Jiasui CHAI
1
;
Jian WANG
;
Zirong LIU
;
Yan LI
;
Zhisheng LI
;
Lianjie NIU
;
Yamin ZHANG
Author Information
1. 天津医科大学一中心临床学院 300192
- Keywords:
Carcinoma,hepatocellular;
NFATC transcription factors;
Immunohistochemistry;
Microvascular invasion
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(3):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of activated T cell nuclear factor (NFAT) in hepatoeellular carcinoma (HCC) tissues and its correlation with clinicopathological factors.Methods Data of 105 patients including 87 males and 18 females,aged 55.1 ± 10.8 years old,diagnosed with HCC who underwent hepatectomy in hepatobiliary surgery department of the first central hospital of Tianjin from September 2014 to December 2016 were retrospectively analyzed,Immunohistochemical staining was used to detect the expression of NFAT subtypes in HCC tissues and adjacent normal liver tissues,and the differences in expression of NFAT subtypes and related factors were analyzed.Results HCC tissues had higher expression of NFAT4 and lower expression of NFAT1 compared to adjacent tissues (P＜0.05).NFAT1 positive group had higher HBV infected rate (93.1％ vs.78.7％) and lower microvascular invasion rate than that in NFAT1 negative group (24.1％ vs.46.8％) (P＜ 0.05).NFAT3 positive group had more younger patients (≤ 60 years old) (80.0％ vs.60.0％) and higher microvascular invasion rate (46.2％ vs.15.0％) (P＜0.05).NFAT4 positive group had higher microvascular invasion rate (43.3％ vs.22.2％) (P＜0.05).Conclusion HCC tissues had different expressions of NFATs.The expressions of NFAT1,NFAT3 and NFAT4 are related to microvascular invasion.
