Analysis of factors influencing recurrence of hepatocellular carcinoma patients after hepatectomy
10.3760/cma.j.issn.1007-8118.2019.03.003
- VernacularTitle:肝细胞癌患者肝切除术后早期复发的影响因素分析
- Author:
Xiaosha SHANG
1
;
Ting NI
;
Wentao WANG
;
Mengsu ZENG
;
Shengxiang RAO
Author Information
1. 复旦大学附属中山医院放射科
- Keywords:
Carcinoma,hepatocellular;
Recurrence;
Computed tomography
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the risk factors of early post-surgical recurrence of hepatocellular carcinoma (HCC) within 2 years.Methods This retrospective study included 178 consecutive patients with HCC who underwent curative resection between January 2009 to December 2012 at Zhongshan Hospital,Fudan University.There were 151 males and 27 females,with a mean age of (58±11) years.The CT features including rim enhancement,satellite nodule,two-trait predictor of venous invasion (TTPVI),and nonsmooth tumor margins were reviewed.After hospital discharge,the patients were followed-up regularly for at least 2 years to detect tumor recurrence.The primary end point was recurrence of HCC.Results On univariate analyses AFP ≥ 200 μg/L,rim enhancement,TTPVI,non-smooth tumor margins and largest diameter ＞5 cm were correlated with early post-surgical recurrence of HCC.On multivariate analyses,AFP≥200 pg/L (HR=2.144,95％CI:1.350～ 3.406),rim enhancement (HR =2.196,95％ CI:1.345 ～ 3.587),TTPVI (HR=1.735,95％CI:1.086～2.772),and non-smooth tumor margins (HR=2.065,95％CI:1.242～3.432) were independent risk factors of early post-surgical recurrence of HCC.Conclusion AFP≥200 μg/L,rim enhancement,TTPVI,and non-smooth tumor margins were independent risk factors of early post-surgical recurrence of HCC.
