Prediction of microvascular invasion in hepatocellular carcinoma patients by preoperative neutrophil-lymphocyte ratio and cancer-related factors
10.3760/cma.j.issn.1007-8118.2019.02.010
- VernacularTitle:术前中性粒细胞与淋巴细胞比值和肿瘤相关因素预测肝癌患者微血管浸润
- Author:
Yanlong YU
1
;
Zhonghua LIU
;
Ying SHI
;
Qiang LI
;
Jiuling SONG
;
Ran ZHANG
;
He LIU
;
Jinming CHEN
Author Information
1. 内蒙古医科大学赤峰临床医学院肝胆外科
- Keywords:
Carcinoma;
hepatocellular;
Alpha fetoprotein (AFP);
Microvascular invasion;
Neutrophil-to-lymphocyte ratio (NLR)
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(2):120-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To predict the presence of MVI,the general clinicopathological of HCC patients' data of the preoperative neutrophil-lymphocyte ratio (NLR),platelet-lymphocyte ratio (PLR),altplatelet ratio (APRI) were evaluated.Methods 143 cases of HCC patients who underwent radical resection and ≤ 5 cm of tumor diameter in Chifeng Clinical Medical School of Inner Mongolia Medical University from January 2011 to December 2014 were analysed retrospectively and followed up.The relationship between NLR,PLR,APRI and other clinical parameters was evaluated.Results According to ROC Curve,the NLR truncation value was 2.00,PLR to 115.00,APRI 1.6.The single factor analysis of x2 test showed that NLR (x2=6.419;P＜0.05),APRI (x2=3.975;P＜0.05),AFP (x2=33.37;P＜0.05),Degree of differentiation (x2 =9.839;P＜0.05) were significant differences between MVI positive (MVI+) and negative (MVI-) groups,and the difference was statistically significant;Logistic regression multifactor analysis showed that NLR (OR 2.678;95％ CI 1.033～6.944;P＜0.05) and AFP (OR 1.724;95％CI 1.023～2.905;P＜0.05) are independent predictors of MVI.Conclusion Preoperative NLR and AFP are convenient,economical and reliable hematological indices for predicting the presence of MVI in HCC patients.
