Analysis of prognostic factors for recurrence of vaginal stump in 493 cases of stageⅠ-ⅡA cervical cancer after radical hysterectomy
10.3760/cma.j.issn.1004-4221.2019.05.007
- VernacularTitle:493例Ⅰ-ⅡA期宫颈癌根治术后残端复发相关因素分析
- Author:
Guangrong LIU
1
;
Li RAN
;
Wei JI
;
Miao YU
;
Jianying CHANG
;
Fenghu LI
;
Jiehui LI
Author Information
1. 贵州医科大学
- Keywords:
Cervical neoplasms/surgery;
Radical operation;
Vaginal stump recurrence;
Cervical neoplasms/external pelvic irradiation;
Cervical neoplasms/brachytherapy
- From:
Chinese Journal of Radiation Oncology
2019;28(5):353-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic factors for the recurrence of vaginal stump of earlystage cervical cancer after radical hysterectomy and evaluate the effect on clinical prognosis.Methods Clinical data of stage Ⅰ-ⅡA cervical cancer patients undergoing radical hysterectomy in Guizhou Cancer Hospital from January,2007 to December,2016 were retrospectively analyzed.Results A total of 493 patients were enrolled and followed up until May 30,2018.Among them,96.6％(474/493) completed the follow-up.The median age was 45 years.Patients aged 40-50 years had a high incidence rate.In total,451 cases (91.48％) had no recurrence of vaginal stump.The average time without stump recurrence was 51.2 months and the median time without stump recurrence was 44.8 months.Multivariate Cox regression analysis demonstrated that pelvic external irradiation and brachytherapy were the independent prognostic factors for the recurrence of vaginal stump (P=0.000,0.000).Tumor size,lymph node metastasis and pelvic external irradiation were the independent prognostic factors for overall survival (P=0.045,0.022,0.000).Conclusions Pelvic external irradiation and brachytherapy play an extremely pivotal role in reducing the risk of vaginal stump recurrence after radical hysterectomy for patients with stage Ⅰ-Ⅱ A cervical cancer.Tumor size,lymph node metastasis and pelvic external irradiation are the independent prognostic factors for overall survival of patients with stage Ⅰ-Ⅱ A cervical cancer following radical hysterectomy.
