Preliminary Observation of Carbon Ion Radiotherapy for Tracheal Adenoid Cystic Carcinoma
10.3760/cma.j.issn.1004-4221.2019.03.002
- VernacularTitle:碳离子射线治疗10例气管腺样囊性癌的初步临床观察
- Author:
Jian CHEN
1
,
2
;
Jingfang MAO
;
Ningyi MA
;
Jiade LU
;
Guoliang JIANG
Author Information
1. 上海市质子重离子医院放疗科 201315
2. 上海质子重离子放射治疗工程技术研究中心 201315
- Keywords:
Tracheal adenoid cystic neoplasms/carbon ion radiotherapy;
Short-term effect
- From:
Chinese Journal of Radiation Oncology
2019;28(3):168-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the short-term effect and toxicities after carbon ion radiotherapy (CIRT) for tracheal adenoid cystic carcinoma (TACC).Methods From March 2016 to October 2017,a total of 10 patients with TACC were treated using CIRT.Among them,three patients had recurrent disease (two after surgery,and one after brachytherapy),one received bronchoscopic cryosurgery for stage Ⅰ disease,and the other 9 had locally advanced disease (3/6 received endoscopic treatment before CIRT).All patients received CIRT using pencil-beam scanning technique.Except that the patient with recurrent disease after brachytherapy received 60 GyE/20 Fx,the patient received cryosurgery and one recurrent patient after surgery received 66 GyE/22 Fx,all other patients received 69 GyE/23 Fx.Results The median follow-up time was 5.5 (1.5-16.4) months.Among the 9 patients with gross tumors,3 patients achieved complete response,2 achieved partial response,and 4 remained stable disease per RECIST 1.1 criteria.The postcryosurgery patient remained no evidence of disease.Except 1 patient experienced grade 4 tracheal stenosis,no other grade ≥ 3 adverse effects were observed.Grade 2 acute toxicities included 1 hoarseness and 1 neutropenia,both relieved after CIRT.Hypothyroidism in one patient was the only observed grade 2 late toxicity.Conclusion CIRT is safe and effective in the management of TACC during a short-time observation.
