Diagnostic value of anti-carbamylate protein antibod for rheumatoid arthritis: a meta analysis
10.3760/cma.j.issn.1007-7480.2019.02.009
- VernacularTitle:抗氨甲酰化蛋白抗体对类风湿关节炎诊断价值的Meta分析
- Author:
Xiao ZHENG
1
;
Xiumei LIU
;
Yumei WANG
Author Information
1. 河北省人民医院风湿免疫科
- Keywords:
Anti-carbamylate protein antibody;
Arthritis,Rheumatoid;
Sensitivity and specificity;
Meta analysis
- From:
Chinese Journal of Rheumatology
2019;23(2):113-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective We aimed to evaluate the diagnostic value of anti-carbamylate protein antibody (anti-CarP antibody) for rheumatoid arthritis (RA).Methods All domestic and foreign database were searched by computerized and manual methods,including PubMed database,Embase database,Cochrane library.All studies about anti-CarP antibody on the diagnostic value of RA were included.The deadline of the search was March 15,2018.Studies that did not meet the population and threshold to select criteria requirements were excluded.Results Manager 5.2,Meta-disc 1.4 and Stata12.0 software were used for literature quality evaluation and statistical analysis.Results A total of 8 papers were included.The heterogeneity test showed that there was heterogeneity caused by nonthreslold effects among the studies,and random effects model was used for Meta analysis.The sensitivity,specificity,positive and negative likelihood ratios of antiCarP antibody for the diagnosis of RA were [45％,95％CI(43％,48％)]、[97％,95％CI(95％,98％)]、[12.65,95％ CI (8.87,18.05)]、[0.56,95％ CI (0.53,0.6)].DOR was [23.97,95％ CI (16.33,35.17)] respectively,and the AUC was 0.777 5.Conclusion Anti-CarP antibody is highly specific for the diagnosis of RA,but its sensitivity is poor.
