Research progress of reactive astrocytes transdifferentiation into neurons for repairing traumatic brain injury
10.3760/cma.j.issn.1001-8050.2019.05.009
- VernacularTitle:反应性星形胶质细胞转分化为神经元修复创伤性脑损伤的研究进展
- Author:
Zining XU
1
,
2
;
Xiaohong LI
;
Yue TU
Author Information
1. 天津中医药大学研究生院 301617
2. 武警部队特色医学中心脑创伤与神经疾病研究所
- Keywords:
Brain injuries;
Astrocytes;
Cell transdifferentiation;
Nerve function
- From:
Chinese Journal of Trauma
2019;35(5):435-440
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury (TBI) is a central nervous system disease with increasing incidence,morbidity and mortality worldwide.TBI can affect the integrity of neuron,causing neuronal axons damage or death of neurons,which results in serious sequelae.After TBI,astrocytes (AST) in the cerebral cortex will be activated into reactive astrocytes (RAS).RAS in the early stage of TBI has a certain repair effect on the injury.However,RAS will proliferate to form glial scars,which has adverse effects on nerve function repair after injury.Therefore,controlling the status of RAS is the key to the treatment of TBI.In recent years,it has been proved that RAS can be transdifferentiated into neurons by transdifferentiation technology,which can not only remove glial scars,but also integrate with the microenvironment at the injury site to replace the injured neurons,which is of great significance for the repair of nerve function after TBI.This article reviews the types of transdifferentiation and the different pathways of RAS transdifferentiation into neurons,aiming to have a better understanding of the research progress of RAS transdifferentiation into neurons to repair TBI.
