Research progress of tyrosine kinase inhibitors in the treatment of pulmonary fibrosis
10.3760/cma.j.issn.1008-6315.2019.03.021
- VernacularTitle:酪氨酸激酶抑制剂在肺纤维化治疗中的研究进展
- Author:
Xiaoxiao HE
1
;
Tian JIANG
;
Shangkun QUAN
;
Xiaohui HAO
Author Information
1. 华北理工大学基础医学院
- Keywords:
Pulmonary fibrosis;
Tyrosine kinase;
Tyrosine kinase inhibitor;
Small molecule target
- From:
Clinical Medicine of China
2019;35(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective Pulmonary fibrosis is a progressive chronic lung disease with a high incidence.Although the path of the disease has not been fully elucidated,the pathogenesis of the disease is roughly similar.Tyrosine kinases are involved in a series of signaling pathways that are critical for cell homeostasis.Substantial evidence from in vitro studies and experimental animal models suggests that tyrosine kinases play a role in promoting the development and progression of pulmonary fibrosis,and tyrosine kinase inhibitors have shown good anti-fibrosis and anti-inflammatory effect in animal models of pulmonary fibrosis.
