Progress in pathogenesis and early diagnosis of Parkinson's disease
10.3760/cma.j.issn.1008-6315.2019.03.019
- VernacularTitle:帕金森病发病机制及其早期诊断的研究进展
- Author:
Ruixia ZHONG
1
;
Yajing QIN
;
Zhongyan CHEN
;
Jingtong ZHANG
;
Shuzhen ZHAO
;
Yang LIU
Author Information
1. 武警特色医学中心脑科中心
- Keywords:
Parkinson's disease;
Mitochondrial dysfunction;
Oxidative stress;
Biomarkers
- From:
Clinical Medicine of China
2019;35(3):276-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective Parkinson's disease (PD) is a common degenerative disease of the central nervous system.The main pathological feature is the reduction of dopaminergic neurons,which induces motion symptoms such as resting tremor,muscle rigidity,bradykinesia,and postural disorder.The etiology and pathogenesis of PD are complex and related to a variety of factors.The current pathogenesis is related to mitochondrial dysfunction,oxidative stress,neuroinflammatory response,apoptosis,and autophagy.The early onset of PD is occult and the rate of misdiagnosis is high.It requires a new simple,safe,and effective early diagnosis method.The current methods of early diagnosis mainly include clinical non-motor symptoms,biomarkers,and imaging examination methods.
