Clinical progress of mesenchymal stem cells in the treatment of osteoarthritis

VernacularTitle:间充质干细胞治疗骨关节炎的临床进展
Author: Yishuang CUI ¹ ; Miao ZHAO ; Xuefeng TENG ; Qian WANG ; Qijia LI
Author Information

1. 华北理工大学基础医学院
Keywords: Mesenchymal stem cells; Osteoarthritis; Articular cartilage
From: Clinical Medicine of China 2019;35(2):187-189
CountryChina
Language:Chinese
Abstract: Osteoarthritis (OA) is slow progressive disease with destruction of articular cartilage and hypertrophy of subchondral bone.The elderly are the most common patients,usually treated by joint surgery.OA patients often undergo total joint replacement.The risk andhigh cost of joint replacement prompt researchers to use multi-potential mesenchymal stem cells to repair full-thickness articular cartilage.Mesenchyma Stem Cells (MSCs) are stromal cells that can differentiate into bone,fat and chondrocytes.MSCs exist in bone marrow and fat.Bone Marrow Mesenchymal Stem Cells (BMSCs) can also be found in synovial joints.MSCs affect the progress of OA.MSCs can be isolated and proliferated in vitro and applied in clinical trials.Current clinical trials are still at an early stage.The primary purpose is to evaluate the safety,feasibility and effectiveness.This article reviews recent progress in clinical trials of MSCs repair of OA.