Correlation between type H hypertension and the development of coronary atherosclerosis Correlation between type H hypertension and the development of coronary atherosclerosis
10.3760/cma.j.issn.1008-6315.2019.02.006
- VernacularTitle:H型高血压患者与冠状动脉粥样硬化病情发生发展之间的相关性
- Author:
Yu ZHANG
1
;
Xinhu LYU
;
Jie GUO
;
Xugang WANG
;
Wei WU
;
Dong MU
;
Yan LIU
Author Information
1. 河北省石家庄市第一医院老年病二科 050091
- Keywords:
Type H hypertension;
Coronary atherosclerosis;
Homocysteine
- From:Clinical Medicine of China
2019;35(2):120-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between type H hypertension and the development of coronary atherosclerosis.Methods From January 2015 to December 2016,three hundred and sixty patients with essential hypertension complicated with coronary atherosclerosis were treated in First Hospital of Shijiazhuang were selected,according to the level of serum homocysteine (Hcy),the patients were divided into the observation group (n =197 cases,Hcy ≥ 10 μ mol/L) and the control group (n =163 cases,Hcy＜10 μmol/L),all patients underwent coronary angiography and intravascular ultrasound.Results The cross-sectional area of extravascular elastic membrane (EEMCSA),plaque area (PA) and plaque burden(PB) of the observed group were (15.10±0.91) mm2,(8.80±0.99) mm2 and (62.03±3.20)％,wrere obviously higher than thoseat of the control group((13.72±0.96) mm2、(7.92±0.89) mm2、(56.87 ±3.37) ％),and the difference was statistically significant (t =14.079,、8.864,and 14.983,P＜0.05),and the minimum lumen cross section area (MLA) was (5.40 ±0.64) mm2,were obviously lower than that of the control group ((5.89 ± 0.52) mm2),and the difference was statistically significant (t =-7.937,P＜0.05);The Gensini score of the coronary artery in the observation group was (67.64± 13.19) points,which was significantly higher than that in the control group ((55.34± 12.20) points),and the difference was statistically significant (t =9.190,P＜0.05);the Serum Hcy were positively correlated with PA,PB and Gensini scores in the observation group (r =0.873,0.732and 0.856,P ＜ 0.05),which was negatively correlated with MLA (r =-0.773,P＜0.05).Conclusion There is a certain correlation between the severity of coronary atherosclerosis and the level of serum Hcy in patients with type H hypertension,which is worthy of further study.
