Study on the effect of pancreatic stone protein in neonatal bacterial infectious diseases
10.3760/cma.j.issn.1008-1372.2019.04.013
- VernacularTitle:胰石蛋白在新生儿细菌感染性疾病中的作用研究
- Author:
Cuihong JI
1
;
Lingmei SONG
;
Meiyu XU
Author Information
1. 上海市奉贤区中心医院儿科 201499
- Keywords:
Infant,newborn;
Bacterial infections;
Lithostathine;
Calcitonin;
C-reactive protein
- From:
Journal of Chinese Physician
2019;21(4):536-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical significance of serum pancreatic stone protein/regenerating protein (PSP/reg) in neonatal bacterial infectious diseases.Methods 92 cases of newborns with bacterial infection in our hospital from June 2016 to May 2017 were enrolled in the study.They were divided into severe infection group (36 cases) and mild infection group (56 cases) according to the severity of the infection.At the same period 58 newborns without infectious diseases in our hospital were also chosen as control group.The serum levels of PSP/reg,procalcitonin (PCT) and C-reactive protein (CRP) were quantitatively measured by enzyme-linked immunosorbent assay (ELISA).Results The serum levels of PSP/reg,PCT and CRP in severe infection group were significantly higher than those in mild infection group (P ＜0.01) and control group (P ＜ 0.01),while the levels of PSP/reg,PCT and CRP in mild infection group were significantly higher than those in control group (P ＜ 0.01).The levels of PSP/reg 3 day after treatment in both severe and mild infection group were significantly lower than those before treatment (P ＜0.01),while the level of PSP/reg in severe infection group was higher than that in another group.After treatment,the levels of PSP/reg,PCT and CRP in the two infection groups were significantly decreased (P ＜0.01),and there was no significant difference between the two groups after healing (P ＞ 0.05).Conclusions The level of PSP/reg is correlated with the severity of neonatal bacterial infectious disease.The change of serum PSP/reg level may be useful in the evaluation of therapy in neonatal bacterial infection.
