Bioinformatics analysis of angiogenesis-related miRNAs in endothelial progenitor cell exosomes
10.3760/cma.j.issn.1008-1372.2019.04.005
- VernacularTitle:内皮祖细胞外泌体中与血管生成相关的miRNAs生物信息学分析
- Author:
Wu XIONG
1
;
Anmeng SUN
;
Yi HUANG
;
Wenjuan QUAN
;
Fengjiao YOU
;
Xulong YANG
;
Hongwei LAN
;
Honghui SU
;
Jianda ZHOU
Author Information
1. 湖南中医药大学第一附属医院烧伤疮疡整形外科
- Keywords:
Endothelial progenitor cells;
Exosomes;
MicroRNAs;
Neovascularization,physiologic;
Bioinformatics
- From:
Journal of Chinese Physician
2019;21(4):499-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective By taking usage of bioinformatics screening methods,this medical research aimed at exploring how the miRNAs in endothelial progenitor cell exosomes relate to the regulation of angiogenesis.Methods miRNAs in endothelial progenitor cells exosomes and angiogenesis-related miRNA was intersected from the existing database to obtain the candidates of miRNA molecules related to angiogenesis in endothelial progenitor exosomes.Results 160 and 50 miRNAs in endothelial progenitor cell candidates were obtained through experimental data analysis and literature searching respectively.600 candidates of angiogenesis-related miRNAs were obtained through literature searching;the top 20 with the highest frequency were selected out.Finally,9 miRNA candidates (miR-126,miR-21,miR-221,miR-92a,miR-199a,miR-210,miR-214,miR-155,miR-146a) that may be highly expressed in endothelial progenitor exosomes and associated with angiogenesis were obtained for the following research.Conclusions Based on data analysis and literature searching,bioinformatics could screen out the target miRNAs for follow-up studies easily and reliably,it is worthy to be widely applied and popularized.
