Application of cholyglycine in common hepatic diseases
10.3760/cma.j.issn.1008-1372.2019.03.017
- VernacularTitle:甘胆酸在常见肝脏疾病中的应用
- Author:
Yunlai LIANG
1
;
Xulin XIE
;
Yupei REN
;
Yating MA
;
Kun WANG
;
Bin YI
Author Information
1. 中南大学湘雅医院检验科
- Keywords:
Glycocholic acid;
Leucyl aminopeptidase;
Bile acids and salts;
Liver diseases
- From:
Journal of Chinese Physician
2019;21(3):387-391
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of glycocholic acid (CG) and evaluate the diagnostic value of CG combined with total bile acid (TBA) and leucine aminopeptidase (LAP) in various liver diseases.Methods From October 2016 to March 2017,210 serum samples of healthy people,asymptomatic hepatitis B virus (HBV) infected,hepatitis,biliary obstruction,hepatocirrhosis and primary hepatocellular carcinoma patients were collected.CG and LAP were detected by corresponding kits,and liver function,coagulation function and other indicators of patients were collected and analyzed statistically.Results The serum level of CG were elevated in the 4 liver disease groups and differed statistically from the normal group or the asymptomatic HBV infected group.CG level was positively correlated with LAP (r =0.380,P ＜ 0.01).In liver function indexes,CG was correlated with total bilirubin (TB),direct bilirubin (DB),TBA and alkaline phosphatase (AKP).At the same time,CG was correlated with fibrinogen(Fib),thrombin time(TT).LAP and TBA were introduced into regression equation Y =-0.835 + 0.157X1 +0.312X2 (X1:LAP,X2:TBA,R2 =0.685) as final variables in multivariate linear regression to analyse the influencing factors of CG.Receiver operator characteristic (ROC) curve analysis showed that CG had the strongest ability to diagnose liver diseases in combination with LAP.Conclusions The change of CG level is of great significance in all kinds of liver diseases.The combination of LAP has the strongest ability to diagnose liver diseases.
