The correlation between the serum level of CEA and vascular endothelial growth factor in diabetes mellitus

VernacularTitle:糖尿病患者CEA与VEGF的关系研究
Author: Shui FU ¹ ; Zihong ZHANG ; Guohua ZHUANG ; Hong LI
Author Information

1. 杭州市余杭区第一人民医院检验科 311000
Keywords: Diabetes mellitus; Carcinoembryonic antigen; Vascular endothelial growth factors; Hemoglobin A,glycosylated
From: Journal of Chinese Physician 2019;21(3):383-386
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between serum carcinoembryonic antigen (CEA) levels and vascular endothelial growth factor (VEGF) levels in diabetics.Methods 92 cases of hospitalized diabetics (they were divided into the pre-treatment group and after-treatment group by intensive hypoglycemic treatment) were collected,and 94 cases of healthy controls were chosen as control group.Serum levels of CEA,hemoglobin Alc (HbAlc),VEGF and another indicators were detected and compared among the three groups.The correlations between VEGF,CEA,and HbA1c were analyzed respectively.Results The serum levels of CEA and VEGF in pre-treatment group were significantly higher than that in after-treatment group and healthy control group.In diabetics,the CEA level was positively correlated with HbA1 c (r =0.91,P ＜ 0.05) and VEGF (r =0.90,P ＜ 0.05),while there was no correlation between HbA1 c and VEGF after intensive treatment (r =0.17,P ＞ 0.05).Conclusions The level of VEGF was positively correlated with CEA,and VEGF maybe one of the pathogenesis of high CEA in diabetes mellitus.