Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia.
10.4142/jvs.2015.16.1.127
- Author:
Hyung Jin PARK
1
;
Ja Won KIM
;
Kun Ho SONG
;
Kyoung Won SEO
Author Information
1. College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea. kwseo@cnu.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
refractory immune-mediated thrombocytopenia;
vincristine-loaded platelets
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic/administration & dosage/*therapeutic use;
Dog Diseases/*therapy;
Dogs;
Female;
Male;
Platelet Transfusion/methods/*veterinary;
Purpura, Thrombocytopenic, Idiopathic/therapy/*veterinary;
Vincristine/administration & dosage/*therapeutic use
- From:Journal of Veterinary Science
2015;16(1):127-130
- CountryRepublic of Korea
- Language:English
-
Abstract:
Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly withimproved clinical signs while the third dogwith recurrent IMT was euthanized due to its deteriorating condition. This case report describesthe efficacy of VLP therapy in refractory IMT patients.
