Association between Peri-Implantitis and Gene Polymorphism of Interleukin-1
- VernacularTitle:白细胞介素-1基因多态性与种植体周围炎的相关性
- Author:
Xiangyu ZHAO
1
;
Liuzhong WU
;
Chun SHI
;
Yongping LU
;
Chuanbo GUO
Author Information
1. 沈阳市口腔医院修复科
- Keywords:
interleukin-1;
peri-implantitis;
gene polymorphism;
relationship
- From:
Journal of China Medical University
2019;48(3):250-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between gene polymorphism of interleukin (IL) -1 and peri-implantitis. Methods A case-control experimental design was used in this study. Moreover, using a bioinformatics analysis, we selected three tagged single nucleotide polymorphisms (SNP) suitable for the Chinese population. Patients with peri-implantitis (n = 116) and 87 patients without peri-implantitis were included. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to tag SNP of IL-1α, IL-1β, and IL-1γn. Results The rs2856838 locus of the AA genotype of IL-1α was associated with a higher risk of implant periodontitis than the GG genotype. There was no statistical difference between the two groups with regard to the other SNP. Conclusion The AA genotype of rs2856838 is associated with periprosthetic inflammation.
