Regulatory Effects of Jinlida Granules on Blood Glucose and Related Factors in Mice with Sugar Stress
10.12007/j.issn.0258-4646.2019.02.015
- VernacularTitle:津力达颗粒对糖负荷小鼠血糖及相关因子的调节作用
- Author:
Yange TANG
1
;
Jing WANG
;
Jiaxiang YANG
Author Information
1. 河北省中医院内分泌科
- Keywords:
Jinlida granules;
diabetes mellitus;
blood lipid
- From:
Journal of China Medical University
2019;48(2):159-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Jinlida granules on blood glucose level, physiological index, and the nuclear factor-kappa B (NF-κB) pathway in mice. Methods Mice were randomly divided into a positive control group (acarbose group), an experimental group (Jinlida granule group), and a blank control group. The effects of Jinlida granules on blood glucose levels and weights of the mice were measured after single and multiple ingestion of sucrose or starch. The levels of superoxide dismutase and malondialdehyde were measured in mice via enzyme-linked immunosorbent assay. Changes in serum lipids and other indicators were detected using an automatic biochemical analyzer in order to determine the regulatory effect of Jinlida granules on blood lipid levels and liver and kidney damage. Changes in NF-κB, interleukin (IL) -1β, and IL-6 levels were detected via Western blotting. Results Jinlida granules downregulated postprandial blood glucose levels without reducing body weight in mice. Jinlida granules also reduced serum triglyceride concentration without causing damage to the liver or kidneys in mice, showed protective effects on muscle cells, and may reduce activation of the NF-κB pathway. Conclusion Jinlida granules may contribute to ameliorating diabetes.
