Relationship between Stat5b Expression in Cervical Tissues and Lesions
10.12007/j.issn.0258-4646.2019.02.012
- VernacularTitle:宫颈组织中Stat5b表达与宫颈病变的关系
- Author:
Si WU
1
;
Yingying WU
;
Miao YU
;
Shuang WANG
;
Changwan CUI
;
Zhengrong SUN
Author Information
1. 中国医科大学附属盛京医院生物样本库
- Keywords:
Stat5b;
cervical lesions/cervical cancer;
immunohistochemistry
- From:
Journal of China Medical University
2019;48(2):144-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of signal transducer and activator of transcription 5 b (Stat5 b) and its phosphorylation (p-Stat5 b) in cervical lesions, its relationship with different degrees of cervical lesions, and its role in the pathogenesis and development of cervical lesions. Methods We obtained 80 specimens, including normal cervical tissues, low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), and cervical cancer tissues. To analyze the correlation between Stat5 b and the degree of cervical lesions, immunohistochemical staining was performed to detect Stat5 b and p-Stat5 b expression. Results Increased Stat5 b expression had a positive correlation with the development of cervical lesions. The percentages of Stat5 b expressed in normal tissues, LSIL, HSIL, and cervical cancer tissues were 15.0％, 0.0％, 50.0％, and 80.0％, respectively, with significant differences among the groups (P ＜ 0.05). Conversely, the expression of p-Stat5 b had a negative correlation with the development of cervical lesions.Expression of p-Stat5 b in normal tissues, LSIL, HSIL, and cervical cancer tissues was 80.0％, 45.0％, 5.0％, and 0.0％, respectively, with statistically significant differences among the groups (P ＜ 0.05). Conclusion The expression of Stat5 b is significantly different in different degrees of cervical lesions, suggesting that Stat5 b signaling molecules may be involved in the development of cervical lesions.
