Effect of Continuous Intravenous Lidocaine Administration for Pain Control in Patients Undergoing Laparoscopic Colorectal Surgery
10.12007/j.issn.0258-4646.2019.02.010
- VernacularTitle:利多卡因持续静脉输注对腹腔镜结直肠手术患者术后疼痛的影响
- Author:
Nanxi ZHAO
1
;
Xuezhao CAO
;
Jun WANG
Author Information
1. 中国医科大学附属第一医院麻醉科
- Keywords:
lidocaine;
analgesia;
laparoscopy;
colorectal surgery
- From:
Journal of China Medical University
2019;48(2):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of continuous intravenous lidocaine administration during surgery for short-term pain control in patients undergoing laparoscopic colorectal surgery, the postoperative use of opioid, and gastrointestinal function recovery. Methods Forty patients who underwent laparoscopic colorectal surgery were randomly assigned to lidocaine and control groups. Each group consisted of 20 patients. The lidocaine group received an intravenous injection of 2％ lidocaine 2 mg/kg during induction of anesthesia, followed by continuous pumping of lidocaine 1.5 mg/ (kg·h) till the end of surgery. In the control group, saline was used in place of lidocaine. The visual analogue scale (VAS), time of first defecation, amount of opioids used intraoperatively and postoperatively, postoperative nausea and vomiting, and lidocaine toxicity symptoms were recorded at 3 h, 12 h, 72 h, 5 d, 7 d, and 30 d after surgery, respectively. Results At3 h, 12 h, 72 h, 5 d, and 7 d (at rest), the VAS scores in the lidocaine group were significantly lower than those in the control group (P ＜0.05). At 72 h (on walking) and 30 d after surgery, no significant differences in VAS scores were found between the two groups. In comparison with the control group, the dosage of opioids in the lidocaine group was significantly reduced (P ＜ 0.05), the recovery of gastrointestinal function was significantly faster (P ＜ 0.05), and the symptom of nausea and vomiting were significantly reduced in the lidocaine group (P ＜ 0.05). No symptoms of lidocaine toxicity were observed in either group. Conclusion Continuous intravenous lidocaine administration during surgery is beneficial for postoperative pain control after laparoscopic colorectal surgery. It can also reduce the use of opioids and accelerate the recovery of gastrointestinal function.
